The standard escalation protocol is: Weeks 14 : 0.25 mg once weekly Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) Patients who experience persistent hunger during the early titration phases should understand that appetite suppression typically increases with higher doses
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Furthermore, programmed necrosis can also be influenced by ROS, which promote the formation of a stable association between two serine/threonine kinases, namely RIP1 and RIP3, which mediate the complex formation of programmed necrosis (Figure 1) (22, 24, 46, 47)
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If you are taking insulin or sulphonylureas alongside GLP-1 medications, these doses may need adjustment when stopping GLP-1 therapy